If you suffer from gum disease in NYC, your periodontist may recommend Arestin as part of your dental treatment plan. Arestin is a safe, effective antibiotic treatment for periodontal disease. Arestin kills the unhealthy, harmful bacteria in and around your gums. When left untreated, these bacteria can cause gingivitis, gum disease, and infection. Arestin is not a pill, but a topical medication that is placed directly in the infected pockets of gum tissue.